Neonatal Abstinence Syndrome (NAS) Incidence and Health Care Costs in the United States, 2016

Authors: Gery Guy, Michele Bohm, MPH, Meghan Frey, MPH, Jean Ko
Publication Year: 2019
Last Updated: 2019-12-18 12:37:56
Journal: JAMA
Keywords: Neonatal Abstinence Syndrome, Opiods, Pediatrics, Infant Mortality

Short Abstract:

This study provides new national incidence and cost estimates for NAS in 2016....

"The overall incidence rate of NAS was 6.7 per 1000 in-hospital births in 2016 (Table 1); rates were highest among American Indian/Alaska Native individuals (15.9 per 1000)"


The study data came from the 2016 Healthcare
Cost and Utilization Project (HCUP) Kids’ Inpatient Database
(KID), a nationally representative sample of all-payer pediatric
discharges.We used the KID variable for in-hospital birth
(I10_HOSPBIRTH) to identify in-hospital births, which were
defined as those with a primary/secondary diagnosis of live
birth and no indication of birth outside the hospital or
transfer from another hospital. Hospitalizations for infants
born with NAS were identified using the International Classification
of Diseases, Tenth Revision, Clinical Modification
(ICD-10-CM) code P96.1 in any diagnosis field.We converted
hospital charges to costs using Healthcare Cost and Utilization
Project hospital–specific cost-to-charge ratios and
adjusted all costs to include physician fees based on the discharge
primary diagnosis.5 We used Stata, version 14.2
(StataCorp) for all analyses and included survey weights to
provide nationally representative estimates. Statistical significance
was set at P< .05. The Centers for Disease Control
and Prevention determined this study to be exempt from
human-subject regulations and institutional review board
approval, and consent was waived because deidentified retrospective
data were used

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